A recent study indicates that patients who stop using popular slimming jabs like semaglutide or tirzepatide may regain lost weight at a significantly accelerated pace than those who halt conventional diet and exercise programs.
Findings released in a leading medical journal points out that while obese individuals often shed a large proportion of their total mass while on the medication, the mass comes back at an average rate of nearly a kilo each month once they quit.
"People using such medications need to be informed of the risk of fast rebound weight gain when the treatment concludes," cautioned researcher Dr. Susan Jebb.
This pace of regain implies a reversion to pre-treatment mass in about 18 months.
Analyzing Approaches
The research, which looked at 37 of trials involving thousands of patients, compared the results of these new drugs with older methods.
Scientists note that individuals who shed pounds through lifestyle changes alone typically see a slower weight regain—perhaps 100 grams monthly—post-intervention.
Explaining the Fast Regain
Experts propose the way of the jabs accounts for the heightened weight return.
GLP-1 drugs imitate a natural hormone called GLP-1, which moderates feelings of fullness.
"Artificially providing GLP-1 concentrations far above than the body's typical production could lead to the system to produce less of its own natural hormone, and may also diminish sensitivity to its effects," noted Dr. Adam Collins, a dietetics researcher.
"Discontinuation of this medication leads to appetite is unsuppressed, making excessive eating a significant risk."
A Chronic Disease?
The NHS suggest the jabs for individuals with obesity-related health risks, accompanied by prescribed diet and exercise modifications.
A number of clinicians say that, considering the high risk of relapse, the therapy is often ongoing.
This opinion is reinforced by drug manufacturers, who note that the findings "emphasize the persistent nature of excess weight," comparing it to managing diseases like hypertension.
Patient Testimonies
Individuals who have come off the jabs describe a powerful return of cravings.
"I experienced a trigger activating and you become starving," recalled a patient.
The struggle is worsened if patients have not established permanent dietary or behavioural modifications during therapy.
Widespread Use
Survey data suggest that a significant number of adults in the UK have tried weight-loss jabs in the last 12 months, with interest being substantial.
- Use is more common among females compared to males.
- The 40s and 50s demographic shows the greatest level of interest.
- A large proportion access the drugs through private prescriptions rather than public health services.
Ultimately, researchers stress that while these medications are potent agents for shedding pounds, they are not a standalone solution and lasting health benefits relies on combined lifestyle changes.
